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KMID : 0360419830190010085
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Korean Journal of Pharmacology
1983 Volume.19 No. 1 p.85 ~ p.92
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Studies on the Adrenergic Alpha-Receptor in the Guinea Pig Ileum
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Abstract
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Intestine is innervated by an interconnected plexus of both sympathetic and parasympathetic nerve fibers. Sympathetic influence causes inhibition of intestinal motility mediated by both α- and 8-adrenergic receptors.
The mechanism of intestinal relaxation by 8-receptors has been extensively studied, but the function of a-receptors in intestinal motility is still unclear.
Although it is suggested that catecholamine reduces acetylcholine release and this may play an important role in a-receptor mediated intestinal relaxation, there is no definite evidences about the mechanism and site of action of a-receptor mediated relaxation. In this experiment, therefore, the effect and site of action of α-receptor agonists were investigated in the guinea pig ileum using electrical field stimulation.
The results are summarized as follows:
1) Electrical field stimulation elicited tonic contraction in isolated guinea pig ileum and this contraction was completely inhibited by the pretreatment of tetrodotoxin or atropine.
2) Norepinephrine, epinephrine and dopamine inhibited the contraction induced by electrical field stimulation but methoxamine and phenylephrine had little effects.
3) Inhibitory effects of norepinephrine and dopamine was partially blocked by yohimbine and phentolamine pretreatment. But haloperidol and propranolol pretreatment cause no effects on the electrical field stimulation induced contraction. Inhibitory effect of dopamine was completely blocked by both haloperidol and yohimbine pretreatment.
4) Inhibitory effects of norepinephrine and dopamine were little affected by the pretreatment with hexamethonium.
It is suggested that electrical field stimulation causes tonic contraction of guinea pig ileum by releasing acetylcholine from postganglionic fiber, and this release is blocked by presynaptic α-receptor activation.
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